CBD Oil for Nausea: Use, Effectiveness, Dosage and More


Also known as cannabidiol, CBD is a naturally occurring cannabinoid in the Cannabis Sativa plant. CBD oil is extracted from industrial hemp plants and has been found to offer a lot of health benefits to the human body. CBD oil for nausea has grown in popularity among many people struggling with nausea. One of the benefits of CBD is alleviating the symptoms of nausea.

However, most people prefer CBD products because they work without the potential psychoactive effects that THC gives. CBD oil is also known to have anti-inflammatory, anti-seizure, anti-tumor, antipsychotic, analgesic, and antioxidant properties.

In this article, we will look at the effectiveness of CBD oil for treating nausea, the clinical studies behind it, dosage, and possible side effects.

A Brief Intro to CBD Oil and Nausea

Researchers have been led to consider the benefits of CBD oil as a treatment of nausea. This is owing to the connection between the endocannabinoid system and nausea. Evidence has indicated that the endocannabinoid system helps to control nausea and vomiting in humans. The ESC also interacts with the digestive system, immune system, and nervous system.

The endocannabinoid system uses receptors to send signals to the body to maintain homeostasis and alter biological responses. When the endocannabinoid system is blocked or impaired, one is likely to feel nauseous. CBD can alter this system. This helps to alleviate nausea symptoms.

Current Research and Studies on CBD and Nausea

Several studies have been published to seek the connection between CBD oil and nausea. Both CBD and THC have been established to effectively manage vomiting and nausea. This is because they interact with the ECS’ CB1 receptors to help reduce nausea and vomiting.

However, there is limited research on the effectiveness of CBD Oil for Nausea, and most studies focus on people with cancer and epilepsy.

In a 2011 study published by Parker L.A in the British Journal of Pharmacology researched concluded that cannabinoid compounds could help alleviate nausea in chemotherapy patients.

In March 2013, a study by Bolognin D was published in the British Journal of Pharmacology, and it established that CBDA, which is an acid form of CBD, was more effective than CBD and THC. Researchers admitted that it is a better antiemetic and is active on serotonin receptors.

Human research done in 2016 found that individuals who experienced nausea due to chemotherapy reported finding relief after taking Sativex than when taking other antiemetic treatments.  Sativex is a medication that contains both CBD and THC, but it has not yet been approved by the Food and Drug Administration (FDA) in the U.S.

What Actually is Nausea and How it Generally Gets Treated?

In general terms, nausea is characterized by the feeling of having an uneasy stomach, which is then followed by the feeling to vomit. It is a defense mechanism that the body uses to eliminate toxins that are found in the digestive tract.

When one is nauseated, they may feel like their stomach is lurching, and the skin gets sweaty. It also comes with feelings of discomfort in the abdomen’s upper part, back of throat, or chest.

The feelings of nausea come from the brainstem, in part known as medulla oblongata. This special region in the brain regulates many involuntary (autonomic) functions like vomiting, sneezing, and breathing. When your body wants to rid the toxic compound sin the digestive tract, the brain will trigger the urge to vomit.

The feeling of nausea may or may not be accompanied by vomiting. However, vomiting can be beneficial because it helps the body rid itself of the toxins that cause nausea.

Some of the causes of nausea include:

  • Infection
  • Food poisoning
  • Motion sickness
  • Migraine headaches
  • Gastroesophageal reflux disease (GERD)
  • Gastrointestinal ulcers
  • Pregnancy
  • Bowel obstruction
  • Some medications like chemotherapy drugs
  • Mental stress and anxiety

Over the years, there have been common remedies for reducing these symptoms. There are nutritional, pharmaceutical, herbal, and lifestyle treatment methods, and most of them work for specific nausea causes. Here are some remedies to manage nausea:

  • Medications like Zofran
  • Relaxation techniques
  • Acupressure
  • Acupuncture
  • Hypnosis
  • Antibiotic medications
  • Opioid pain medications
  • Peppermint
  • Ginger root
  • Biofeedback
  • Music therapy
  • Breathing techniques

Home Remedies for Controlling Nausea

Here are some Home remedies for controlling nausea and vomiting include:

  • Eat and drink slowly.
  • Don’t skip meals
  • Avoid brushing your teeth after eating.
  • Only eat small portions.
  • Consume non-oily foods
  • Avoid high-sugar foods
  • Eat either all hot or all cold foods. Avoid mixing both hot and cold foods.
  • Only eat foods that you can easily hold down.
  • Drink clear iced drinks
  • If you vomit, drink a lot of clear liquids and gradually increase them
  • If you are taking medications that cause nausea, consult with your doctor whether it is possible to discontinue them.
  • Keep hydrated throughout the day.
  • Eat food before going for chemotherapy treatment.

Cannabidiol Oil and its Effectiveness to Treat Nausea

The feelings of nausea and vomiting can control by parts of the brain that also manage other functions involuntary functions.

CBD oil is believed to work on two types of cannabinoid receptors found in the endocannabinoid system. These receptors include the CB1 and CB2 receptors. The CB1 receptors are in the brain and lower concentration in the body. On the other hand, the CB2 receptors are found throughout the body, particularly in organs and immune system cells.

Since these receptors are found throughout the body, the endocannabinoid system can identify various problems whenever there is an imbalance. If you start to feel nauseated, it will interact with the CB2 receptors and signal the digestive system.

Nausea and vomiting are caused by a chemical known as serotonin (5-hydroxytryptamine/ 5-HT). This chemical is released from the cells found in the gastrointestinal tract cells when toxins enter the body. It then activates the 5-HT3 and the 5-HT4, which are receptors found in the vagus nerve. This sends a signal to the centers of the brain that are responsible for   causing nausea and vomiting.

To reduce nausea, researchers believe that Cannabidiol oil combines with CB1 receptors to reduce the release of serotonin. CBD oil interacts with serotonin 5-HT3 receptors to lower the binding of serotonin with the receptor, resulting in reduced feelings of nausea.

CBD oil has also been found to be an effective treatment for nausea that is caused by motion sickness. Oftentimes, motion sickness comes because the endocannabinoid system is impaired. CBD can alter this system to help alleviate nausea.

Mixing CBD Oil with Other Anti-Nausea Herbs: Does it Help?

Unknown to many people, CBD oil can be mixed with other anti-nausea herbs to give maximum benefits for treating nausea. Anti-nausea herbs work through separate mechanisms to effectively reduce nausea.

When mixed with the best CBD oils, the anti-nausea herbs produce stronger effects to give maximum anti-nausea benefits quickly.  This strategy works better than using single anti-nausea herbs. The herbs can be taken as capsules, tinctures, or even strong tea.

Some of the anti-nausea herbs that can be mixed with CBD oil to give quick relief include peppermint, ginger, chamomile, and lemon balm.

Dosage Guide for CBD Oil for Nausea

Currently, there are no recommendations that show the right dosage for CBD in treating nausea. Nonetheless, it is important to note that CBD works differently for each person; hence, the dosage may vary with the user and their condition.

In terms of nausea, some people need low strength to find relief while others find relief after taking high-strength doses.

You will only know what works best for you by trying out various dosages. Start with a low dose and gradually increase the dose until you find relief. It is also vital to follow a trustworthy CBD Buyer’s Guide and consult with your doctor for more information on the best dosage.

Side Effects to Consider

CBD oil may have possible side effects despite being well-tolerated by most people. What works for one person may not work for another. Here are some of the potential side-effects of CBD:

  • Dry mouth
  • Drowsiness
  • Diarrhea
  • Reduced appetite
  • Fatigue
  • Nausea
  • Lower heart rate
  • Sedation

It is also important to note that CBD may interact and interfere with other drugs. Therefore, if you are taking other medications, it is best to consult with your doctor before using CBD products.

In addition, pregnant and breastfeeding women are advised to avoid CBD products. This is also true for children unless they are doing so due to advice from a medical practitioner.

Are There Any Legal Issues Related to Getting CBD Oil?

Basically, the CBD legal status is still a concern to many people. CBD products derived from hemp and have less than 0.3% THC are considered legal federally. However, they may still be illegal in some states. Therefore, the legality of hemp-derived CBD products varies greatly with the state that you are in.

On the other hand, CBD products that are derived from cannabis are illegal federally. However, they may be legal in various state laws.

Overall, it is best to avoid those products that are extracted from marijuana since they contain higher THC quantities. Instead, opt for hemp-derived products with lower THC quantities of 0.3%.


Because of its biological properties, CBD oil can be a natural treatment for nausea. It can be used to alleviate different causes of nausea and use where other drugs have been proven ineffective. Although it has mild side-effects, the positives outweigh the negatives.

There is an increasing number of studies that concentrate on establishing the effects of CBD oil on nausea. More studies on the benefits of cannabinoid for treating nausea are expected in the coming years.

Nonetheless, nausea patients are advised to opt for hemp-derived CBD products. This is because industrial-hemp products contain little traces of THC. Also, make sure to make your purchase from Premium CBD Brands that offer high-quality products.